For thirty years now, Monika Sprüth and Philomene Magers have been accompanying, promoting, and supporting the developments of contemporary art. Monika Sprüth opened her gallery in 1983, Philomene Magers made her start in 1991; both were located in Cologne at that time. Their shared enthusiasm for working with diverse artistic positions in the areas of Conceptual Art, Minimalism, feminism, and photography led to a merging of the two galleries in 1998. A second gallery space in Munich followed soon, and in 2003 Sprüth Magers opened their gallery in London Mayfair. Since the move from Cologne and Munich to Berlin in 2008, the gallery is to be found on extensive premises in direct neighborhood to the Museum Island.

Monika Sprüth and Philomene Magers represent such established artists as Barbara Kruger, Cindy Sherman, Rosemarie Trockel, Louise Lawler, and Jenny Holzer, as well as famous photographers such as Bernd & Hilla Becher, Andreas Gursky, and Thomas Demand. Important positions in post-modernism such as Peter Fischli & David Weiss, Louise Lawler, and the painters Andreas Schulze, George Condo, and Thomas Scheibitz have been represented by Sprüth Magers, mostly exclusively, for thirty years now. The top-class program of the gallery is enriched by artists classified as Minimalists, like Donald Judd and Dan Flavin, as well as by important representatives of American Concept Art, including Robert Morris, John Baldessari, Richard Artschwager, and Ed Ruscha. This spectrum is broadened by young artists such as Thea Djordjadze, Michael Pirgelis Cyprien Gaillard, David Maljkovic, Alexandre Singh, Ryan Trecartin, and Andro Wekua.